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This product contains a blend of adaptogenic botanicals specifically formulated to strengthen the body’s stress response and support healthy energy levels. This product provides a unique blend of “stress adapting botanicals” which help increase the body’s resistance to fatigue, improve attention and immune function and maintain balanced cortisol and DHEA levels.

 


 
 

 

Overview

Stress is defined as any disturbance—extreme cold or heat, psychological stress, sleep deprivation, work overload, physical trauma, as well as toxic exposure—that can trigger the stress response. The body’s stress response system is comprised of the hypothalamic-pituitary-adrenal (HPA) axis. Prolonged stress triggers the HPA axis and consists of three stages: stage 1: alarm; stage 2: resistance; and stage 3: exhaustion.

The initial, short-lived phase (the alarm phase) is the body’s normal fight-or flight response to danger which is characterized by elevated cortisol levels. The next phase, the resistance phase, allows the body to continue buffering extended stress exposure, long after the initial fight-or-flight response has dissipated. Hormones released by the adrenals, such as cortisol and DHEA, help support the “resistance” reaction. However, extended periods of stress not only burden the system, creating an imbalance in cortisol and DHEA production, but can result in mental and physical fatigue, nervous tension, irritability, poor memory and decreased immunity—all of which are characteristic of stage 3. This product provides a unique blend of botanicals that support the body’s ability to respond to and counteract the negative effects of stress.

 

Holy Basil

Holy basil (Ocimum sanctum) is an adaptogenic herb that enhances the body’s stress and immune response. A comprehensive review of 24 human studies has revealed positive therapeutic effects of holy basil on neurocognition, immunity and metabolism.1 Thirty-five subjects were dosed with Ocimum sanctum and it was found to have a statistically significant promise to help support low mood and attention.2

 

Ashwagandha Root Extract†

Ashwagandha’s strong adaptogenic properties provide an array of benefits for individuals that have compromised health due to extreme stress exposure. Ashwagandha’s benefits include improving stress resilience, supporting immune response, regulating the sleep cycle, supporting healthy thyroid function and protecting against exhaustion of the nervous system.3,4 Ashwagandha has also been shown to be beneficial in supporting proper mood regulation and restoring a sense of calmness under stress.4  of Rhodiola twice daily and saw a significant reduction in fatigue.6 An additional study using Rhodiola extract in students showed significant improvements in mental performance, greater mood stability and improved sleep patterns.7

 

Eleuthero Root Extract†

Eleutherococcus senticosus has been identified as a strong adaptogenic botanical and is widely used in China to improve general health, support memory and physical endurance.8 In addition to its ability to improve stress resilience and maintain energy, Eleuthero has been shown to support the immune system.9 In a double -blind study, the adaptogenic effects of Eleuthero were demonstrated to help maintain a sense of calmness, reflected by a reduction of heart rate, during stress exposure.10 Eleuthero has also been shown to improve performance in runners. In a study on performance athletes, Eleuthero extract (2 or 4 mL) given 30 minutes prior to a race significantly reduced race time (48.7 minutes) compared to the control group (52.6 minutes).11

 

Schisandra Berry Extract†

Schisandra is an adaptogenic botanical that has been used for centuries in China and Russia to help support mental clarity, stress response and emotional wellness. In a double-blind, placebo-controlled study, athletes were given Schisandra chinensis and Bryonia alba extracts or placebo. Those receiving the therapy had increased concentrations of nitric oxide, a molecule which causes the blood vessels to expand resulting in increased circulation, increased blood flow and nutrients throughout the body.12 The researchers concluded that schisandra provides supportive factors for physical performanceinathletes.12 Schisandraberryhasbeenshownto support learning and memory and may have some protective factors that support brain health.13

 

Licorice Root Extract†

The primary components in licorice root that support adrenal health include glycyrrhetic acid and glycyrrhizin. Licorice has also been shown to block 11-β-hydroxysteroid dehydrogenase, the enzyme responsible for the conversion of cortisol to the inactive cortisone. When taken in small doses, licorice root extract can be used to maintain normal cortisol levels, an important factor for individuals that need to support adrenal hormone production and maintain healthy inflammatory pathways.14

 


 

Directions

2 capsules one or two times per day or as recommended by your health care professional.

Does Not Contain

Wheat, gluten, corn, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners or preservatives.

Cautions
If you are pregnant or nursing, consult your physician before
taking this product.

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References

  1. Jamshidi N, Cohen MM. The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature. Evid Based Complement Alternat Med. 2017;2017:9217567.

  2. Bhattacharyya D, Sur TK, Jana U, Debnath PK. Controlled programmed trial of Ocimum sanctum leaf on generalized anxiety disorders. Nepal Med Coll J. 2008 Sep; 10(3):176-9.

  3. Mishra, LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 2000; 5(4):334-346.

  4. Withaniasomnifera.Monograph.AlternMed Review 2004;9(2):211-214.

  5. Rhodiola rosea. Altern Med Review 2002;7 (5):421-423.

  6. Shevtsov, VA, Zholus BI, et al. A randomized trial
    of two different doses of a SHR-5 Rhodiola rosea
    extract versus placebo and control of capacity for mental work. Phytomedicine 2003; 10(2-3):95-105.

  7. Spasov AA, Wikman GK, Mandrikov, et al. A double blind, placebo controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine 2000;7:85-89.

  8. American Botanical Council. American Botanical Council. Eleuthero root. http://www.herbalgram.org. 2002.

  9. Eleutherococcus senticosus. Altern Med Review 2006;(11):2.

  10. FacchinettiF,NeriI,TarabusiM.Eleutherococcus senticosus reduces cardiovascular response in healthy subjects: a randomized, placebo-controlled trial. Stress Health 2002; 18:11-17.

  11. HalsteadBW,HoodLL.Eleutherococcus
    senticosus /Siberian ginseng: An introduction
    to the Concept of Adaptogenic Medicine. Long Beach, CA: Oriental Healing Arts Institute; 1984:28.

  12. Panossian,AG,OganessianAS,etal.Effectsofheavy physical exercise and adaptogens on nitric oxide content in human saliva. Phytomedicine. 1999; 6(1):17-26.

  13. KangSY,LeeKY,etal.ESP-102,astandardized combined extract of Angelica gigas, Saururus chinensis and Schizandra chinensis, significantly improved scopolamine-induced memory impairment in mice. Life Sci 2005; 76(15):1691-1705.

  14. Guilliams TG, Edwards L. Chronic Stress and the HPA Axis. The Standard 2010;9(2).



† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.